Association of Health-Related Quality of Life with Functional and Radiological Outcomes in Patients with Rheumatoid Arthritis–Associated Interstitial Lung Disease, Systemic Sclerosis–Associated Interstitial Lung Disease, and Idiopathic Pulmonary Fibrosis
Irem Sahinoğlu1
, Deniz Kizilirmak2, Sadettin Uslu1, Mevlüt Kacar1, Filiz Cemre Tasgöz1, Seref Sülükcü1, Emre Ali Acar1, Müge Gencer Tuluy2, Secil Sari3, Ozgül Soysal Gündüz1, Timur Pirildar1
1 Department of Rheumatology, Celal Bayar University School of Medicine, Manisa, Türkiye
2 Department of Chest Diseases, Celal Bayar University School of Medicine, Manisa, Türkiye
3 Department of Physiotherapy, Celal Bayar University School of Medicine, Manisa, Türkiye
Keywords: Idiopathic pulmonary fibrosis, interstitial lung disease, rheumatoid arthritis, Saint George Respiratory Questionnaire, systemic sclerosis, Warrick scoring system
Abstract
Background/Aims: This study aimed to investigate the association between lung function and imaging parameters with health-related quality of life (HRQoL), as measured by the St. George’s Respiratory Questionnaire (SGRQ), in patients with rheumatoid arthritis–associated interstitial lung disease (RA-ILD), systemic sclerosis–associated ILD (SSc-ILD), and idiopathic pulmonary fibrosis (IPF).
Materials and Methods: In this cross-sectional study, a total of 120 patients (37 RA-ILD, 42 SSc-ILD, and 41 IPF) were included. Demographic, clinical, functional (forced vital capacity [FVC], lung diffusion capacity for carbon monoxide [DLCO], 6 minute walk test), and radiological (Warrick scores) data were collected. The associations between SGRQ scores and these parameters, as well as other patient-reported outcome measures (PROMs), were analyzed.
Results: St. George’s Respiratory Questionnaire scores showed significant correlations with functional measures and PROMs across all groups. However, no correlation was found between SGRQ and FVC only in RA-ILD. In SSc-ILD and IPF, SGRQ scores were also significantly associated with high-resolution computed tomography–based Warrick scores. However, no correlation was found between SGRQ and radiological parameters in RA-ILD. Receiver operating characteristic (ROC) analysis demonstrated that SGRQ could help identify patients with impaired lung function (FVC <70%) in IPF and SSc-ILD groups.
Conclusion: St. George’s Respiratory Questionnaire may be a valuable tool for evaluating HRQoL in patients with SSc-ILD and IPF, with moderate associations with functional and radiological outcomes. Its utility in RA-ILD appears to be more limited and requires further investigation.
Cite this article as: Sahinoğlu I, Kizilirmak D, Uslu S, et al. Association of health-related quality of life with functional and radiological outcomes in patients with rheumatoid arthritis–associated interstitial lung disease, systemic sclerosis–associated interstitial lung disease, and idiopathic pulmonary fibrosis. Arch Rheumatol. 2025;40(3):299-307.